A. Valance Washington

A. Valance Washington
教授,Ph值.D.
313 DH
(248) 370-4495
[email protected]
Washington lab website

课程:

BIO 4629 Scientific Inquiry

研究:

Whether just a cut, or life-threatening pneumonia, we have all experienced the effects of inflammation. Accumulating evidence suggests that the small anucleate cells called platelets regulate both the intensity and outcomes of many of the body’s inflammatory responses. Dr. Washington’s laboratory studies a platelet receptor called TLT-1 (the Triggering Receptor Expressed in Myeloid cells (TREM) Like Transcript -1) that seems to function at the interface of hemostasis, mediated by platelets, and inflammation directed by the immune system. His laboratory uses basic biochemistry, 动物模型, and human subjects to unravel novel mechanisms by which platelets interaction with the immune system direct disease outcomes.

Selected Publications:

Valance Washington List of Publications

Branfield,年代., & 华盛顿,. V. (2020). Control the platelets, control the disease: A novel cystic fibrosis hypothesis. Journal of Thrombosis and Haemostasis, 18(7), 1531-1534. doi: http://doi.org/10.1111/jth.14868.

Morales-Ortíz, J.成交，成交，成交.雷耶斯，F., Maldonado-Martínez, G.莱德斯马，n.n.斯塔巴克，F., . . . 华盛顿,. V. (2018). Platelet-derived TLT-1 is a prognostic indicator in ALI/ARDS and prevents tissue damage in the lungs in a mouse model. 血,132(23), 2495-2505. doi:10.1182/blood-2018-03-841593.

华盛顿,. V.阿斯庞达，奥., & 吉布森,. (2020). Platelet biology of the rapidly failing lung. British Journal of Haematology, 188(5), 641-651. doi: http://doi.org/10.1111/bjh.16315.

华盛顿,. V.吉伯特，S.阿塞韦多，我.加蒂斯，J.L .奎格利.费尔兹，R., . . . McVicar D. W. (2009). TREM-like transcript-1 protects against inflammation-associated hemorrhage by facilitating platelet aggregation in mice and humans. The Journal of Clinical Investigation, 119(6), 1489-1501. doi: 10.1172 / JCI36175.

华盛顿,. V.舒伯特，R. L.L .奎格利.狄斯皮奥，T.费尔兹，R.， Cho, E. H., & McVicar D. W. (2004). A TREM family member, TLT-1, is found exclusively in the α-granules of megakaryocytes and platelets. 血,104(4), 1042-1047. doi: 10.1182/blood-2004-01-0315.